Discovery of a Novel, Isothiazolonaphthoquinone-Based Small Molecule Activator of FOXO Nuclear-Cytoplasmic Shuttling

FOXO factors are tumour suppressor proteins commonly inactivated in human tumours by posttranslational modifications. Furthermore, genetic variation within the FOXO3a gene is consistently associated with human longevity. Therefore, the pharmacological activation of FOXO proteins is considered as an...

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Detalles Bibliográficos
Autores principales: Cautain, Bastien, Castillo, Francisco, Musso, Loana, Ferreira, Bibiana I., de Pedro, Nuria, Rodriguez Quesada, Lorena, Machado, Susana, Vicente, Francisca, Dallavalle, Sabrina, Link, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147912/
https://www.ncbi.nlm.nih.gov/pubmed/27936162
http://dx.doi.org/10.1371/journal.pone.0167491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147912/
https://www.ncbi.nlm.nih.gov/pubmed/27936162
http://dx.doi.org/10.1371/journal.pone.0167491

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