Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase

[Image: see text] Homotetrameric R67 dihydrofolate reductase possesses 222 symmetry and a single active site pore. This situation results in a promiscuous binding site that accommodates either the substrate, dihydrofolate (DHF), or the cofactor, NADPH. NADPH interacts more directly with the protein...

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Detalles Bibliográficos
Autores principales: Duff, Michael R., Chopra, Shaileja, Strader, Michael Brad, Agarwal, Pratul K., Howell, Elizabeth E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147970/
https://www.ncbi.nlm.nih.gov/pubmed/26637016
http://dx.doi.org/10.1021/acs.biochem.5b00981

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147970/
https://www.ncbi.nlm.nih.gov/pubmed/26637016
http://dx.doi.org/10.1021/acs.biochem.5b00981

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