Cargando…

Tales of Dihydrofolate Binding to R67 Dihydrofolate Reductase

[Image: see text] Homotetrameric R67 dihydrofolate reductase possesses 222 symmetry and a single active site pore. This situation results in a promiscuous binding site that accommodates either the substrate, dihydrofolate (DHF), or the cofactor, NADPH. NADPH interacts more directly with the protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Duff, Michael R., Chopra, Shaileja, Strader, Michael Brad, Agarwal, Pratul K., Howell, Elizabeth E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5147970/ https://www.ncbi.nlm.nih.gov/pubmed/26637016 http://dx.doi.org/10.1021/acs.biochem.5b00981

Ejemplares similares

Small Angle Neutron Scattering Studies of R67 Dihydrofolate Reductase, a Tetrameric Protein with Intrinsically Disordered N-Termini
por: Bhojane, Purva P., et al.
Publicado: (2017)

Binding of Natural and Synthetic Polyphenols to Human Dihydrofolate Reductase
por: Sánchez-del-Campo, Luís, et al.
Publicado: (2009)

Adaptations for Pressure and Temperature in Dihydrofolate Reductases
por: Penhallurick, Ryan W., et al.
Publicado: (2021)

Minimization of dynamic effects in the evolution of dihydrofolate reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2016)

Temperature-Dependent Kinetic Isotope Effects in R67 Dihydrofolate Reductase from Path-Integral Simulations
por: Mhashal, Anil R., et al.
Publicado: (2021)

Different Dynamical Effects in Mesophilic and Hyperthermophilic Dihydrofolate Reductases
por: Luk, Louis Y. P., et al.
Publicado: (2014)

The Role of Large-Scale Motions in Catalysis by Dihydrofolate Reductase
por: Loveridge, E. Joel, et al.
Publicado: (2011)

Computational analysis of binding between malarial dihydrofolate reductases and anti-folates
por: Choowongkomon, Kiattawee, et al.
Publicado: (2010)

Evolution Alters the Enzymatic Reaction Coordinate of Dihydrofolate Reductase
por: Masterson, Jean E., et al.
Publicado: (2014)

Side Chain Conformational Averaging in Human Dihydrofolate Reductase
por: Tuttle, Lisa M., et al.
Publicado: (2014)

Divergent evolution of protein conformational dynamics in dihydrofolate reductase
por: Bhabha, Gira, et al.
Publicado: (2013)

Effects of Distal Mutations on Ligand-Binding Affinity in E. coli Dihydrofolate Reductase
por: Huang, Chen-Hua, et al.
Publicado: (2021)

Dihydrofolate reductase as a model for studies of enzyme dynamics and catalysis
por: Kohen, Amnon
Publicado: (2015)

A calibration curve for immobilized dihydrofolate reductase activity assay
por: Singh, Priyanka, et al.
Publicado: (2015)

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes
por: Askari, Bahram S., et al.
Publicado: (2010)

Lausannevirus Encodes a Functional Dihydrofolate Reductase Susceptible to Proguanil
por: Mueller, L., et al.
Publicado: (2017)

Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
por: Xu, Guodong, et al.
Publicado: (2020)

Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase
por: Wang, Yinghui, et al.
Publicado: (2021)

Computational Development of Inhibitors of Plasmid-Borne Bacterial Dihydrofolate Reductase
por: Silva, Pedro J.
Publicado: (2022)

Thermal Adaptation of Dihydrofolate Reductase from the Moderate Thermophile Geobacillus stearothermophilus
por: Guo, Jiannan, et al.
Publicado: (2014)

Capturing the Catalytic Proton of Dihydrofolate Reductase: Implications for General Acid–Base Catalysis
por: Wan, Qun, et al.
Publicado: (2021)

Multiple origins of resistance-conferring mutations in Plasmodium vivax dihydrofolate reductase
por: Hawkins, Vivian N, et al.
Publicado: (2008)

Study on Folate Binding Domain of Dihydrofolate Reductase in Different Plant species and Human beings
por: Samanta, Aveek, et al.
Publicado: (2014)

Hybrid Inhibitors of Malarial Dihydrofolate Reductase with Dual Binding Modes That Can Forestall Resistance
por: Tarnchompoo, Bongkoch, et al.
Publicado: (2018)

Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase
por: Adesina, Aduragbemi S., et al.
Publicado: (2021)

Dihydrofolate Reductase Inhibitors: The Pharmacophore as a Guide for Co-Crystal Screening
por: Baptista, João A., et al.
Publicado: (2021)

Combined gene deletion of dihydrofolate reductase-thymidylate synthase and pteridine reductase in Leishmania infantum
por: Bhattacharya, Arijit, et al.
Publicado: (2021)

Dihydrofolate Reductase I164L Mutation in Plasmodium falciparum, Madagascar
por: Ménard, Didier, et al.
Publicado: (2008)

Optimized peptide based inhibitors targeting the dihydrofolate reductase pathway in cancer
por: Singh, Amrinder, et al.
Publicado: (2018)

Molecular Docking Analysis of Pyrimethamine Derivatives with Plasmodium falciparum Dihydrofolate Reductase
por: Singh, Indra Vikram, et al.
Publicado: (2018)

Molecular Characteristics and Serodiagnostic Potential of Dihydrofolate Reductase from Echinococcus granulosus
por: Song, Xingju, et al.
Publicado: (2017)

A comparative molecular docking study of curcumin and methotrexate to dihydrofolate reductase
por: Hobani, Yahya, et al.
Publicado: (2017)

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
por: Santucci, Matteo, et al.
Publicado: (2021)

Histidine Hydrogen-Deuterium Exchange Mass Spectrometry for Probing the Microenvironment of Histidine Residues in Dihydrofolate Reductase
por: Miyagi, Masaru, et al.
Publicado: (2011)

Plasmodium dihydrofolate reductase is a second enzyme target for the antimalarial action of triclosan
por: Bilsland, Elizabeth, et al.
Publicado: (2018)

Why Are Some Enzymes Dimers? Flexibility and Catalysis in Thermotoga maritima Dihydrofolate Reductase
por: Ruiz-Pernía, J. Javier, et al.
Publicado: (2019)

Loss of Hyperconjugative Effects Drives Hydride Transfer during Dihydrofolate Reductase Catalysis
por: Angelastro, Antonio, et al.
Publicado: (2019)

Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen – A cautionary tale in screening transgenic parasites
por: Tran, Phuong N., et al.
Publicado: (2016)

Substrate Specificity Analysis of Dihydrofolate/Dihydromethanopterin Reductase Homologs in Methylotrophic α-Proteobacteria
por: Burton, Mark, et al.
Publicado: (2018)

The implication of dihydrofolate reductase and dihydropteroate synthetase gene mutations in modification of Plasmodium falciparum characteristics
por: A-Elbasit, Ishraga E, et al.
Publicado: (2007)

Cannot write session to /tmp/vufind_sessions/sess_7k0jce18df0k26bl9rlghqgrqp