HbS Binding to GP1bα Activates Platelets in Sickle Cell Disease

Intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our previous study showed that the binding of adult hemoglobin (HbA) to glycoprotein (GP) 1bα induced the activation of platelets. The elevated plasma Hb or platelet surface bound Hb positively correlated with platelet...

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Detalles Bibliográficos
Autores principales: Annarapu, Gowtham K., Singhal, Rashi, Gupta, Avinash, Chawla, Sheetal, Batra, Harish, Seth, Tulika, Guchhait, Prasenjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148012/
https://www.ncbi.nlm.nih.gov/pubmed/27936141
http://dx.doi.org/10.1371/journal.pone.0167899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148012/
https://www.ncbi.nlm.nih.gov/pubmed/27936141
http://dx.doi.org/10.1371/journal.pone.0167899

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