Structural Analysis of Thymidylate Synthase from Kaposi’s Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a highly infectious human herpesvirus that causes Kaposi’s sarcoma. KSHV encodes functional thymidylate synthase, which is a target for anticancer drugs such as raltitrexed or 5-fluorouracil. Thymidylate synthase catalyzes the conversion of 2′-deoxyu...

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Detalles Bibliográficos
Autores principales: Choi, Yong Mi, Yeo, Hyun Ku, Park, Young Woo, Lee, Jae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148040/
https://www.ncbi.nlm.nih.gov/pubmed/27936107
http://dx.doi.org/10.1371/journal.pone.0168019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148040/
https://www.ncbi.nlm.nih.gov/pubmed/27936107
http://dx.doi.org/10.1371/journal.pone.0168019

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