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Structural Analysis of Thymidylate Synthase from Kaposi’s Sarcoma-Associated Herpesvirus with the Anticancer Drug Raltitrexed

Kaposi’s sarcoma-associated herpesvirus (KSHV) is a highly infectious human herpesvirus that causes Kaposi’s sarcoma. KSHV encodes functional thymidylate synthase, which is a target for anticancer drugs such as raltitrexed or 5-fluorouracil. Thymidylate synthase catalyzes the conversion of 2′-deoxyu...

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Detalles Bibliográficos
Autores principales:	Choi, Yong Mi, Yeo, Hyun Ku, Park, Young Woo, Lee, Jae Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148040/ https://www.ncbi.nlm.nih.gov/pubmed/27936107 http://dx.doi.org/10.1371/journal.pone.0168019

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