Trehalose-6-Phosphate-Mediated Toxicity Determines Essentiality of OtsB2 in Mycobacterium tuberculosis In Vitro and in Mice

Trehalose biosynthesis is considered an attractive target for the development of antimicrobials against fungal, helminthic and bacterial pathogens including Mycobacterium tuberculosis. The most common biosynthetic route involves trehalose-6-phosphate (T6P) synthase OtsA and T6P phosphatase OtsB that...

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Detalles Bibliográficos
Autores principales: Korte, Jan, Alber, Marina, Trujillo, Carolina M., Syson, Karl, Koliwer-Brandl, Hendrik, Deenen, René, Köhrer, Karl, DeJesus, Michael A., Hartman, Travis, Jacobs, William R., Bornemann, Stephen, Ioerger, Thomas R., Ehrt, Sabine, Kalscheuer, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148154/
https://www.ncbi.nlm.nih.gov/pubmed/27936238
http://dx.doi.org/10.1371/journal.ppat.1006043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148154/
https://www.ncbi.nlm.nih.gov/pubmed/27936238
http://dx.doi.org/10.1371/journal.ppat.1006043

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