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Using the Amino Acid Network to Modulate the Hydrolytic Activity of β-Glycosidases

The active site residues in GH1 β-glycosidases are compartmentalized into 3 functional regions, involved in catalysis or binding of glycone and aglycone motifs from substrate. However, it still remains unclear how residues outside the active site modulate the enzymatic activity. To tackle this quest...

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Detalles Bibliográficos
Autores principales: Tamaki, Fábio K., Souza, Diorge P., Souza, Valquiria P., Ikegami, Cecilia M., Farah, Chuck S., Marana, Sandro R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148593/
https://www.ncbi.nlm.nih.gov/pubmed/27936116
http://dx.doi.org/10.1371/journal.pone.0167978