“Marker of Self” CD47 on lentiviral vectors decreases macrophage-mediated clearance and increases delivery to SIRPA-expressing lung carcinoma tumors

Lentiviruses infect many cell types and are now widely used for gene delivery in vitro, but in vivo uptake of these foreign vectors by macrophages is a limitation. Lentivectors are produced here from packaging cells that overexpress “Marker of Self” CD47, which inhibits macrophage uptake of cells wh...

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Detalles Bibliográficos
Autores principales: Sosale, Nisha G, Ivanovska, Irena I, Tsai, Richard K, Swift, Joe, Hsu, Jake W, Alvey, Cory M, Zoltick, Philip W, Discher, Dennis E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148596/
https://www.ncbi.nlm.nih.gov/pubmed/28053997
http://dx.doi.org/10.1038/mtm.2016.80

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148596/
https://www.ncbi.nlm.nih.gov/pubmed/28053997
http://dx.doi.org/10.1038/mtm.2016.80

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