Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell culture conditions. We developed a pipeline for...

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Detalles Bibliográficos
Autores principales: Ma, Siming, Upneja, Akhil, Galecki, Andrzej, Tsai, Yi-Miau, Burant, Charles F, Raskind, Sasha, Zhang, Quanwei, Zhang, Zhengdong D, Seluanov, Andrei, Gorbunova, Vera, Clish, Clary B, Miller, Richard A, Gladyshev, Vadim N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148604/
https://www.ncbi.nlm.nih.gov/pubmed/27874830
http://dx.doi.org/10.7554/eLife.19130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148604/
https://www.ncbi.nlm.nih.gov/pubmed/27874830
http://dx.doi.org/10.7554/eLife.19130

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