The effects of the novel A53E alpha-synuclein mutation on its oligomerization and aggregation

α-synuclein (aSyn) is associated with both sporadic and familial forms of Parkinson’s disease (PD), the second most common neurodegenerative disorder after Alzheimer’s disease. In particular, multiplications and point mutations in the gene encoding for aSyn cause familial forms of PD. Moreover, the...

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Detalles Bibliográficos
Autores principales: Lázaro, Diana F., Dias, Mariana Castro, Carija, Anita, Navarro, Susanna, Madaleno, Carolina Silva, Tenreiro, Sandra, Ventura, Salvador, Outeiro, Tiago F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148884/
https://www.ncbi.nlm.nih.gov/pubmed/27938414
http://dx.doi.org/10.1186/s40478-016-0402-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148884/
https://www.ncbi.nlm.nih.gov/pubmed/27938414
http://dx.doi.org/10.1186/s40478-016-0402-8

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