ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

BACKGROUND: Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for autophagosome biogenesis. However, it isn’t fully understood how ULK1 regulates V...

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Detalles Bibliográficos
Autores principales: Wold, Mitchell S., Lim, Junghyun, Lachance, Véronik, Deng, Zhiqiang, Yue, Zhenyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148922/
https://www.ncbi.nlm.nih.gov/pubmed/27938392
http://dx.doi.org/10.1186/s13024-016-0141-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148922/
https://www.ncbi.nlm.nih.gov/pubmed/27938392
http://dx.doi.org/10.1186/s13024-016-0141-0

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