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A (99m)Tc-tricine-HYNIC-labeled Peptide Targeting the Melanocortin-1 Receptor for Melanoma Imaging

Melanocortin-1 (MC1) receptor is an attractive melanoma-specific target for the development of α-MSH peptide based imaging and therapeutic agents. In this work a new lactam bridge α-MSH analogue was synthesized and radiolabeled with (99m)Tc via HYNIC chelator and tricine as co-ligand. Also, stabilit...

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Detalles Bibliográficos
Autores principales: Shamshirian, Danial, Erfani, Mostafa, Beiki, Davood, Hajiramazanali, Maliheh, Fallahi, Babak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shaheed Beheshti University of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149022/
https://www.ncbi.nlm.nih.gov/pubmed/27980570