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Extensive Proliferation of a Subset of Differentiated, yet Plastic, Medial Vascular Smooth Muscle Cells Contributes to Neointimal Formation in Mouse Injury and Atherosclerosis Models

RATIONALE: Vascular smooth muscle cell (VSMC) accumulation is a hallmark of atherosclerosis and vascular injury. However, fundamental aspects of proliferation and the phenotypic changes within individual VSMCs, which underlie vascular disease, remain unresolved. In particular, it is not known whethe...

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Detalles Bibliográficos
Autores principales: Chappell, Joel, Harman, Jennifer L., Narasimhan, Vagheesh M., Yu, Haixiang, Foote, Kirsty, Simons, Benjamin D., Bennett, Martin R., Jørgensen, Helle F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5149073/
https://www.ncbi.nlm.nih.gov/pubmed/27682618
http://dx.doi.org/10.1161/CIRCRESAHA.116.309799