Antimicrobial mechanism of theaflavins: They target 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway

1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is the first committed enzyme in the 2-methyl-D-erythritol 4-phosphate (MEP) terpenoid biosynthetic pathway and is also a validated antimicrobial target. Theaflavins, which are polyphenolic compounds isolated from fermented tea, possess a wide ra...

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Detalles Bibliográficos
Autores principales: Hui, Xian, Yue, Qiao, Zhang, Dan-Dan, Li, Heng, Yang, Shao-Qing, Gao, Wen-Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150241/
https://www.ncbi.nlm.nih.gov/pubmed/27941853
http://dx.doi.org/10.1038/srep38945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150241/
https://www.ncbi.nlm.nih.gov/pubmed/27941853
http://dx.doi.org/10.1038/srep38945

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