VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity

Most of neurodegenerative disorders are associated with protein aggregation. Glutamate-induced excitotoxicity and persistent extracellular signal-regulated kinase (ERK) activation are also implicated in neurodegenerative diseases. Here, we found that vaccinia-related kinase 3 (VRK3) facilitates nucl...

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Detalles Bibliográficos
Autores principales: Song, Haengjin, Kim, Wanil, Kim, Sung-Hoon, Kim, Kyong-Tai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150261/
https://www.ncbi.nlm.nih.gov/pubmed/27941812
http://dx.doi.org/10.1038/srep38452

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150261/
https://www.ncbi.nlm.nih.gov/pubmed/27941812
http://dx.doi.org/10.1038/srep38452

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