Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability

Disulfide bonds play a key role in stabilizing protein structures, with disruption strongly associated with loss of protein function and activity. Previous data have suggested that disulfides show only modest reactivity with oxidants. In the current study, we report kinetic data indicating that sele...

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Detalles Bibliográficos
Autores principales: Karimi, Maryam, Ignasiak, Marta T., Chan, Bun, Croft, Anna K., Radom, Leo, Schiesser, Carl H., Pattison, David I., Davies, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150571/
https://www.ncbi.nlm.nih.gov/pubmed/27941824
http://dx.doi.org/10.1038/srep38572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150571/
https://www.ncbi.nlm.nih.gov/pubmed/27941824
http://dx.doi.org/10.1038/srep38572

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