Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease

[Image: see text] Spermine conjugates 2–6, carrying variously decorated 3,5-dibenzylidenepiperidin-4-one as bioactive motives, were designed to direct antiaggregating properties into mitochondria, using a polyamine functionality as the vehicle tool. The study confirmed mitochondrial import of the ca...

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Detalles Bibliográficos
Autores principales: Simoni, Elena, Caporaso, Roberta, Bergamini, Christian, Fiori, Jessica, Fato, Romana, Miszta, Przemyslaw, Filipek, Sławomir, Caraci, Filippo, Giuffrida, Maria Laura, Andrisano, Vincenza, Minarini, Anna, Bartolini, Manuela, Rosini, Michela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2016
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150688/
https://www.ncbi.nlm.nih.gov/pubmed/27994754
http://dx.doi.org/10.1021/acsmedchemlett.6b00339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5150688/
https://www.ncbi.nlm.nih.gov/pubmed/27994754
http://dx.doi.org/10.1021/acsmedchemlett.6b00339

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