Cooperativity of Negative Autoregulation Confers Increased Mutational Robustness

Negative autoregulation is universally found across organisms. In the bacterium Escherichia coli, transcription factors often repress their own expression to form a negative feedback network motif that enables robustness to changes in biochemical parameters. Here we present a simple phenomenological...

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Detalles Bibliográficos
Autores principales: Marciano, David C., Lua, Rhonald C., Herman, Christophe, Lichtarge, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152588/
https://www.ncbi.nlm.nih.gov/pubmed/27391757
http://dx.doi.org/10.1103/PhysRevLett.116.258104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5152588/
https://www.ncbi.nlm.nih.gov/pubmed/27391757
http://dx.doi.org/10.1103/PhysRevLett.116.258104

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