Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations

The FLT3 Internal Tandem Duplication (FLT3(ITD)) mutation is common in adult acute myeloid leukemia (AML) but rare in early childhood AML. It is not clear why this difference occurs. Here we show that Flt3(ITD) and cooperating Flt3(ITD)/Runx1 mutations cause hematopoietic stem cell depletion and mye...

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Detalles Bibliográficos
Autores principales: Porter, Shaina N, Cluster, Andrew S, Yang, Wei, Busken, Kelsey A, Patel, Riddhi M, Ryoo, Jiyeon, Magee, Jeffrey A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153248/
https://www.ncbi.nlm.nih.gov/pubmed/27879203
http://dx.doi.org/10.7554/eLife.18882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153248/
https://www.ncbi.nlm.nih.gov/pubmed/27879203
http://dx.doi.org/10.7554/eLife.18882

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