Low kidney uptake of GLP-1R-targeting, beta cell-specific PET tracer, (18)F-labeled [Nle(14),Lys(40)]exendin-4 analog, shows promise for clinical imaging

BACKGROUND: Several radiometal-labeled, exendin-based tracers that target glucagon-like peptide-1 receptors (GLP-1R) have been intensively explored for β cell imaging. The main obstacle has been the high uptake of tracer in the kidneys. This study aimed to develop a novel GLP1-R-specific tracer, wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Mikkola, Kirsi, Yim, Cheng-Bin, Lehtiniemi, Paula, Kauhanen, Saila, Tarkia, Miikka, Tolvanen, Tuula, Nuutila, Pirjo, Solin, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153397/
https://www.ncbi.nlm.nih.gov/pubmed/27957723
http://dx.doi.org/10.1186/s13550-016-0243-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153397/
https://www.ncbi.nlm.nih.gov/pubmed/27957723
http://dx.doi.org/10.1186/s13550-016-0243-2

Ejemplares similares