The ability of human nuclear DNA to cause false positive low-abundance heteroplasmy calls varies across the mitochondrial genome

BACKGROUND: Low-abundance mutations in mitochondrial populations (mutations with minor allele frequency ≤ 1%), are associated with cancer, aging, and neurodegenerative disorders. While recent progress in high-throughput sequencing technology has significantly improved the heteroplasmy identification...

Descripción completa

Detalles Bibliográficos
Autores principales: Albayrak, Levent, Khanipov, Kamil, Pimenova, Maria, Golovko, George, Rojas, Mark, Pavlidis, Ioannis, Chumakov, Sergei, Aguilar, Gerardo, Chávez, Arturo, Widger, William R., Fofanov, Yuriy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153897/
https://www.ncbi.nlm.nih.gov/pubmed/27955616
http://dx.doi.org/10.1186/s12864-016-3375-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153897/
https://www.ncbi.nlm.nih.gov/pubmed/27955616
http://dx.doi.org/10.1186/s12864-016-3375-x

Ejemplares similares