Downregulation of peroxiredoxin-3 by hydrophobic bile acid induces mitochondrial dysfunction and cellular senescence in human trophoblasts

Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-specific disorder characterised by raised bile acids in foetal-maternal circulation, which threatens perinatal health. During the progression of ICP, the effect of oxidative stress is underscored. Peroxiredoxin-3 (PRDX3) is a mitochondrial a...

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Detalles Bibliográficos
Autores principales: Wu, Wei-Bin, Menon, Ramkumar, Xu, Yue-Ying, Zhao, Jiu-Ru, Wang, Yan-Lin, Liu, Yuan, Zhang, Hui-Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154184/
https://www.ncbi.nlm.nih.gov/pubmed/27958341
http://dx.doi.org/10.1038/srep38946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154184/
https://www.ncbi.nlm.nih.gov/pubmed/27958341
http://dx.doi.org/10.1038/srep38946

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