Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV(+) cells

High-risk human papillomaviruses (HR-HPVs) cause nearly all cases of cervical cancer, as well as approximately 30% of head and neck cancers. HPV 16 E6, one of two major viral oncogenes, protects cells from apoptosis by binding to and accelerating the degradation of several proteins important in apop...

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Detalles Bibliográficos
Autores principales: Yuan, C-H, Filippova, M, Krstenansky, J L, Duerksen-Hughes, P J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154303/
https://www.ncbi.nlm.nih.gov/pubmed/26794656
http://dx.doi.org/10.1038/cddis.2015.391

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154303/
https://www.ncbi.nlm.nih.gov/pubmed/26794656
http://dx.doi.org/10.1038/cddis.2015.391

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