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Targeting telomerase with radiolabeled inhibitors

The expression of telomerase in approximately 85% of cancers and its absence in the majority of normal cells makes it an attractive target for cancer therapy. However the lag period between initiation of telomerase inhibition and growth arrest makes direct inhibition alone an insufficient method of...

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Detalles Bibliográficos
Autores principales: Waghorn, Philip A., Jackson, Mark R., Gouverneur, Veronique, Vallis, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154340/
https://www.ncbi.nlm.nih.gov/pubmed/27657809
http://dx.doi.org/10.1016/j.ejmech.2016.09.028