Gain of function of mutant p53: R282W on the peak?

Mutant p53 proteins commonly lose their tumor suppression function and gain novel oncogenic functions (gain of function (GOF)). Different p53 mutations are often considered in one class in biological and clinical studies. However, recent studies have revealed that p53 mutations are biologically and...

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Detalles Bibliográficos
Autores principales: Zhang, Y, Coillie, S V, Fang, J-Y, Xu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154345/
https://www.ncbi.nlm.nih.gov/pubmed/26878390
http://dx.doi.org/10.1038/oncsis.2016.8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154345/
https://www.ncbi.nlm.nih.gov/pubmed/26878390
http://dx.doi.org/10.1038/oncsis.2016.8

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