Heparanase-induced shedding of syndecan-1/CD138 in myeloma and endothelial cells activates VEGFR2 and an invasive phenotype: prevention by novel synstatins

Multiple myeloma arises when malignant plasma cells invade and form multiple tumors in the bone marrow. High levels of heparanase (HPSE) correlate with poor prognosis in myeloma patients. A likely target of the enzyme is the heparan sulfate (HS) proteoglycan syndecan-1 (Sdc1, CD138), which is highly...

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Detalles Bibliográficos
Autores principales: Jung, O, Trapp-Stamborski, V, Purushothaman, A, Jin, H, Wang, H, Sanderson, R D, Rapraeger, A C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154350/
https://www.ncbi.nlm.nih.gov/pubmed/26926788
http://dx.doi.org/10.1038/oncsis.2016.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154350/
https://www.ncbi.nlm.nih.gov/pubmed/26926788
http://dx.doi.org/10.1038/oncsis.2016.5

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