Cdc48-independent proteasomal degradation coincides with a reduced need for ubiquitylation

Ubiquitin fusion degradation (UFD) substrates are delivered at the proteasome by a handover mechanism involving the ubiquitin-selective chaperone Cdc48 and the ubiquitin shuttle factor Rad23. Here, we show that introduction of a 20 amino acid peptide extension not only rendered degradation independe...

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Detalles Bibliográficos
Autores principales: Gödderz, Daniela, Heinen, Christian, Marchese, Francesco P., Kurz, Tilman, Acs, Klàra, Dantuma, Nico P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154593/
https://www.ncbi.nlm.nih.gov/pubmed/25556859
http://dx.doi.org/10.1038/srep07615

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154593/
https://www.ncbi.nlm.nih.gov/pubmed/25556859
http://dx.doi.org/10.1038/srep07615

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