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Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA

We reported that mesenchymal stromal cells (MSCs) enhance neurological recovery from experimental stroke and increase tissue plasminogen activator (tPA) expression in astrocytes. Here, we investigate mechanisms by which tPA mediates MSC enhanced axonal outgrowth. Primary murine neurons and astrocyte...

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Detalles Bibliográficos
Autores principales: Qian, Jian-Yong, Chopp, Michael, Liu, Zhongwu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154605/
https://www.ncbi.nlm.nih.gov/pubmed/27959956
http://dx.doi.org/10.1371/journal.pone.0168345