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Novel guanidinylated bioresponsive poly(amidoamine)s designed for short hairpin RNA delivery

Two different disulfide (SS)-containing poly(amidoamine) (PAA) polymers were constructed using guanidino (Gua)-containing monomers (ie, arginine [Arg] and agmatine [Agm]) and N,N′-cystamine bisacrylamide (CBA) by Michael-addition polymerization. In order to characterize these two Gua-SS-PAA polymers...

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Detalles Bibliográficos
Autores principales: Yu, Jiankun, Zhang, Jinmin, Xing, Haonan, Sun, Yanping, Yang, Zhen, Yang, Tianzhi, Cai, Cuifang, Zhao, Xiaoyun, Yang, Li, Ding, Pingtian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154728/
https://www.ncbi.nlm.nih.gov/pubmed/27994462
http://dx.doi.org/10.2147/IJN.S115773