Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression

In mice, generation of autoreactive CD5(+) B cells occurs as a consequence of BCR signaling induced by (self)-ligand exposure from fetal/neonatal B-1 B cell development. A fraction of these cells self-renew and persist as a minor B1 B cell subset throughout life. Here, we show that transfer of early...

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Detalles Bibliográficos
Autores principales: Hayakawa, Kyoko, Formica, Anthony M., Brill-Dashoff, Joni, Shinton, Susan A., Ichikawa, Daiju, Zhou, Yan, Morse, Herbert C., Hardy, Richard R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154941/
https://www.ncbi.nlm.nih.gov/pubmed/27899442
http://dx.doi.org/10.1084/jem.20160712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154941/
https://www.ncbi.nlm.nih.gov/pubmed/27899442
http://dx.doi.org/10.1084/jem.20160712

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