Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from ar...

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Detalles Bibliográficos
Autores principales: Tchetina, Elena V., Markova, Galina A., Poole, A. Robin, Zukor, David J., Antoniou, John, Makarov, Sergey A., Kuzin, Aleksandr N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155111/
https://www.ncbi.nlm.nih.gov/pubmed/28042296
http://dx.doi.org/10.1155/2016/6432867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155111/
https://www.ncbi.nlm.nih.gov/pubmed/28042296
http://dx.doi.org/10.1155/2016/6432867

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