TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (miRNA) biogenesis remains unknown. Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in...

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Detalles Bibliográficos
Autores principales: Fareh, Mohamed, Yeom, Kyu-Hyeon, Haagsma, Anna C., Chauhan, Sweeny, Heo, Inha, Joo, Chirlmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155159/
https://www.ncbi.nlm.nih.gov/pubmed/27934859
http://dx.doi.org/10.1038/ncomms13694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155159/
https://www.ncbi.nlm.nih.gov/pubmed/27934859
http://dx.doi.org/10.1038/ncomms13694

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