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TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA-binding protein TRBP is a central component of the Dicer complex. Despite a decade of biochemical and structural studies, the essential functionality of TRBP in microRNA (miRNA) biogenesis remains unknown. Here we show that TRBP is an integral cofactor for time-efficient Dicer processing in...

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Detalles Bibliográficos
Autores principales:	Fareh, Mohamed, Yeom, Kyu-Hyeon, Haagsma, Anna C., Chauhan, Sweeny, Heo, Inha, Joo, Chirlmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155159/ https://www.ncbi.nlm.nih.gov/pubmed/27934859 http://dx.doi.org/10.1038/ncomms13694

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