C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure

AIM: To investigate the role of the complement 5a (C5a)/C5a receptor (C5aR) pathway in the pathogenesis of acute liver failure (ALF) in a mouse model. METHODS: BALB/c mice were randomly assigned to different groups, and intraperitoneal injections of lipopolysaccharide (LPS)/D-galactosamine (D-GalN)...

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Detalles Bibliográficos
Autores principales: Lei, Yan-Chang, Lu, Chun-Lei, Chen, Ling, Ge, Ke, Yang, Ling-Ling, Li, Wen, Wu, Yuan-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Basic Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155174/
https://www.ncbi.nlm.nih.gov/pubmed/28028363
http://dx.doi.org/10.3748/wjg.v22.i46.10148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155174/
https://www.ncbi.nlm.nih.gov/pubmed/28028363
http://dx.doi.org/10.3748/wjg.v22.i46.10148

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