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C5a/C5aR pathway is essential for up-regulating SphK1 expression through p38-MAPK activation in acute liver failure
AIM: To investigate the role of the complement 5a (C5a)/C5a receptor (C5aR) pathway in the pathogenesis of acute liver failure (ALF) in a mouse model. METHODS: BALB/c mice were randomly assigned to different groups, and intraperitoneal injections of lipopolysaccharide (LPS)/D-galactosamine (D-GalN)...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Baishideng Publishing Group Inc
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155174/ https://www.ncbi.nlm.nih.gov/pubmed/28028363 http://dx.doi.org/10.3748/wjg.v22.i46.10148 |