Efficient Generation of Orthologous Point Mutations in Pigs via CRISPR-assisted ssODN-mediated Homology-directed Repair

Precise genome editing in livestock is of great value for the fundamental investigation of disease modeling. However, genetically modified pigs carrying subtle point mutations were still seldom reported despite the rapid development of programmable endonucleases. Here, we attempt to investigate sing...

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Detalles Bibliográficos
Autores principales: Wang, Kankan, Tang, Xiaochun, Liu, Yan, Xie, Zicong, Zou, Xiaodong, Li, Mengjing, Yuan, Hongming, Ouyang, Hongsheng, Jiao, Huping, Pang, Daxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155319/
https://www.ncbi.nlm.nih.gov/pubmed/27898095
http://dx.doi.org/10.1038/mtna.2016.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155319/
https://www.ncbi.nlm.nih.gov/pubmed/27898095
http://dx.doi.org/10.1038/mtna.2016.101

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