Evaluation of recombinant monoclonal antibody SVmab1 binding to Na (V)1.7 target sequences and block of human Na (V)1.7 currents

Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na (V)1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind the Na (V)1.7 DII voltage sensor domain and block...

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Detalles Bibliográficos
Autores principales: Liu, Dong, Tseng, Mandy, Epstein, Linda F., Green, Lydia, Chan, Brian, Soriano, Brian, Lim, Desiree, Pan, Oscar, Murawsky, Christopher M., King, Chadwick T., Moyer, Bryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2016
Materias:
Antibody Validation Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155501/
https://www.ncbi.nlm.nih.gov/pubmed/27990272
http://dx.doi.org/10.12688/f1000research.9918.1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155501/
https://www.ncbi.nlm.nih.gov/pubmed/27990272
http://dx.doi.org/10.12688/f1000research.9918.1

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