Cargando…

Evaluation of recombinant monoclonal antibody SVmab1 binding to Na (V)1.7 target sequences and block of human Na (V)1.7 currents

Identification of small and large molecule pain therapeutics that target the genetically validated voltage-gated sodium channel Na (V)1.7 is a challenging endeavor under vigorous pursuit. The monoclonal antibody SVmab1 was recently published to bind the Na (V)1.7 DII voltage sensor domain and block...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Dong, Tseng, Mandy, Epstein, Linda F., Green, Lydia, Chan, Brian, Soriano, Brian, Lim, Desiree, Pan, Oscar, Murawsky, Christopher M., King, Chadwick T., Moyer, Bryan D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000Research 2016
Materias:	Antibody Validation Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155501/ https://www.ncbi.nlm.nih.gov/pubmed/27990272 http://dx.doi.org/10.12688/f1000research.9918.1

Ejemplares similares

Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts
por: Grainger, Deborah L., et al.
Publicado: (2016)

Comparative study of commercially available and homemade anti-VAMP7 antibodies using CRISPR/Cas9-depleted HeLa cells and VAMP7 knockout mice
por: Verraes, Agathe, et al.
Publicado: (2019)

Optimized purification strategies for the elimination of non-specific products in the isolation of GAD65-specific monoclonal autoantibodies
por: Jiang, Wei, et al.
Publicado: (2016)

Monoclonal antibodies against muscle actin isoforms: epitope identification and analysis of isoform expression by immunoblot and immunostaining in normal and regenerating skeletal muscle
por: Chaponnier, Christine, et al.
Publicado: (2016)

Immunoblotting validation of research antibodies generated against HS1-associated protein X-1 in the human neutrophil model cell line PLB-985.
por: Cavnar, Peter, et al.
Publicado: (2015)

Na(v)1.7 and Na(v)1.8: Role in the pathophysiology of pain
por: Hameed, Shaila
Publicado: (2019)

Structural mapping of Na(v)1.7 antagonists
por: Wu, Qiurong, et al.
Publicado: (2023)

Unexpected lack of specificity of a rabbit polyclonal TAP-L (ABCB9) antibody
por: van Endert, Peter, et al.
Publicado: (2015)

Antibody performance in ChIP-sequencing assays: From quality scores of public data sets to quantitative certification
por: Mendoza-Parra, Marco-Antonio, et al.
Publicado: (2016)

Referencing cross-reactivity of detection antibodies for protein array experiments
por: Lemass, Darragh, et al.
Publicado: (2017)

Validation of commercially available sphingosine kinase 2 antibodies for use in immunoblotting, immunoprecipitation and immunofluorescence
por: Neubauer, Heidi A., et al.
Publicado: (2017)

Validation of a yeast malate dehydrogenase 2 (Mdh2) antibody tested for use in western blots
por: Gabay-Maskit, Shiran, et al.
Publicado: (2018)

Validation of commercial ERK antibodies against the ERK orthologue of the scleractinian coral Stylophora pistillata
por: Courtial, Lucile, et al.
Publicado: (2017)

Validation of a commercial antibody to detect endogenous human nicastrin by immunoblot
por: Mesa, Rosana A., et al.
Publicado: (2020)

Complementary roles of murine Na(V)1.7, Na(V)1.8 and Na(V)1.9 in acute itch signalling
por: Kühn, Helen, et al.
Publicado: (2020)

Neuropathic pain develops normally in mice lacking both Na(v)1.7 and Na(v)1.8
por: Nassar, Mohammed A, et al.
Publicado: (2005)

Defining the Functional Role of Na(V)1.7 in Human Nociception
por: McDermott, Lucy A., et al.
Publicado: (2019)

Na(V)1.6 and Na(V)1.7 channels are major endogenous voltage-gated sodium channels in ND7/23 cells
por: Lee, Jisoo, et al.
Publicado: (2019)

Na(v)1.7 expression is increased in painful human dental pulp
por: Luo, Songjiang, et al.
Publicado: (2008)

Hydropathicity-based prediction of pain-causing NaV1.7 variants
por: Xenakis, Makros N., et al.
Publicado: (2021)

Paclitaxel increases axonal localization and vesicular trafficking of Na(v)1.7
por: Akin, Elizabeth J, et al.
Publicado: (2021)

Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes Na(V)1.9, Na(V)1.7 and Na(V)1.1
por: Touska, Filip, et al.
Publicado: (2017)

Discovery of a selective, state-independent inhibitor of Na(V)1.7 by modification of guanidinium toxins
por: Pajouhesh, H., et al.
Publicado: (2020)

Spider venom-derived peptide induces hyperalgesia in Na(v)1.7 knockout mice by activating Na(v)1.9 channels
por: Zhou, Xi, et al.
Publicado: (2020)

Synthetic Analogues of Huwentoxin-IV Spider Peptide With Altered Human Na(V)1.7/Na(V)1.6 Selectivity Ratios
por: Lopez, Ludivine, et al.
Publicado: (2021)

Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na(v)1.7 and Na(v)1.5
por: Bok, Chan-Su, et al.
Publicado: (2023)

Na(v)1.7 is the predominant sodium channel in rodent olfactory sensory neurons
por: Ahn, Hye-Sook, et al.
Publicado: (2011)

Rare Na(V)1.7 variants associated with painful diabetic peripheral neuropathy
por: Blesneac, Iulia, et al.
Publicado: (2018)

The voltage-gated sodium channel Na(v)1.7 associated with endometrial cancer
por: Liu, Junxiu, et al.
Publicado: (2019)

Selective optogenetic activation of Na(V)1.7–expressing afferents in Na(V)1.7-ChR2 mice induces nocifensive behavior without affecting responses to mechanical and thermal stimuli
por: Maruta, Toyoaki, et al.
Publicado: (2022)

Building sensory axons: Delivery and distribution of Na(V)1.7 channels and effects of inflammatory mediators
por: Akin, Elizabeth J., et al.
Publicado: (2019)

Conservation and divergence in NaChBac and Na(V)1.7 pharmacology reveals novel drug interaction mechanisms
por: Zhu, Wandi, et al.
Publicado: (2020)

Comparison of Gating Properties and Use-Dependent Block of Na(v)1.5 and Na(v)1.7 Channels by Anti-Arrhythmics Mexiletine and Lidocaine
por: Wang, Ying, et al.
Publicado: (2015)

Roles of Voltage-Gated Tetrodotoxin-Sensitive Sodium Channels Na(V)1.3 and Na(V)1.7 in Diabetes and Painful Diabetic Neuropathy
por: Yang, Linlin, et al.
Publicado: (2016)

The Changes in Expression of Na(V)1.7 and Na(V)1.8 and the Effects of the Inhalation of Their Blockers in Healthy and Ovalbumin-Sensitized Guinea Pig Airways
por: Kocmalova, Michaela, et al.
Publicado: (2021)

Network topology of NaV1.7 mutations in sodium channel-related painful disorders
por: Kapetis, Dimos, et al.
Publicado: (2017)

Upregulation of Na(v)1.7 by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain
por: Tian, Jun-Jie, et al.
Publicado: (2020)

Sensory neuron–derived Na(V)1.7 contributes to dorsal horn neuron excitability
por: Alles, Sascha R. A., et al.
Publicado: (2020)

Osteoarthritis-dependent changes in antinociceptive action of Na(v)1.7 and Na(v)1.8 sodium channel blockers: An in vivo electrophysiological study in the rat
por: Rahman, W., et al.
Publicado: (2015)

Monoclonal Antibody Against Stromal Cell-Derived Factor 2
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_98kvp3o5hrgbvvmec8ni0877cv