Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology

Currently, drug discovery approaches commonly assume a monotonic dose-response relationship. However, the assumption of monotonicity is increasingly being challenged. Here we show that for two simple interacting linear signaling pathways that carry two different signals with different physiological...

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Detalles Bibliográficos
Autores principales: van Wijk, Roeland, Tans, Sander J., Wolde, Pieter Rein ten, Mashaghi, Alireza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155565/
https://www.ncbi.nlm.nih.gov/pubmed/26087464
http://dx.doi.org/10.1038/srep11376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155565/
https://www.ncbi.nlm.nih.gov/pubmed/26087464
http://dx.doi.org/10.1038/srep11376

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