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Non-monotonic dynamics and crosstalk in signaling pathways and their implications for pharmacology
Currently, drug discovery approaches commonly assume a monotonic dose-response relationship. However, the assumption of monotonicity is increasingly being challenged. Here we show that for two simple interacting linear signaling pathways that carry two different signals with different physiological...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155565/ https://www.ncbi.nlm.nih.gov/pubmed/26087464 http://dx.doi.org/10.1038/srep11376 |