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Asymmetric addition of α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid
We describe the asymmetric addition of unactivated α-branched cyclic ketones to allenamides catalyzed by a chiral phosphoric acid, generating an all-carbon quaternary stereocenter with broad substrate scope and high enantioselectivity. The products are easily transformed into their corresponding 1,5...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Royal Society of Chemistry
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5155590/ https://www.ncbi.nlm.nih.gov/pubmed/27990248 http://dx.doi.org/10.1039/c5sc04202j |