The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets. All members of the Coronavirinae, a subfamily of positi...

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Detalles Bibliográficos
Autores principales: Fehr, Anthony R., Channappanavar, Rudragouda, Jankevicius, Gytis, Fett, Craig, Zhao, Jincun, Athmer, Jeremiah, Meyerholz, David K., Ahel, Ivan, Perlman, Stanley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156301/
https://www.ncbi.nlm.nih.gov/pubmed/27965448
http://dx.doi.org/10.1128/mBio.01721-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156301/
https://www.ncbi.nlm.nih.gov/pubmed/27965448
http://dx.doi.org/10.1128/mBio.01721-16

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