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Src kinase as a mediator of convergent molecular abnormalities leading to NMDAR hypoactivity in schizophrenia

Numerous investigations support decreased glutamatergic signaling as a pathogenic mechanism of schizophrenia: yet molecular underpinnings for such dysregulation are largely unknown. In the postmortem dorsolateral prefrontal cortex, we found striking decreases in tyrosine phosphorylation of N-methyl-...

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Detalles Bibliográficos
Autores principales: Banerjee, Anamika, Wang, Hoau-Yan, Borgmann-Winter, Karin E., MacDonald, Mathew L., Kaprielian, Hagop, Stucky, Andres, Kvasic, Jessica, Egbujo, Chijioke, Ray, Rabindranath, Talbot, Konrad, Hemby, Scott E, Siegel, Steven J., Arnold, Steven E., Sleiman, Patrick, Chang, Xiao, Hakonarson, Hakon, Gur, Raquel E., Hahn, Chang-Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156326/
https://www.ncbi.nlm.nih.gov/pubmed/25330739
http://dx.doi.org/10.1038/mp.2014.115