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Effect of Regulatory Element DNA Methylation on Tissue-Type Plasminogen Activator Gene Expression

Expression of the tissue-type plasminogen activator gene (t-PA; gene name PLAT) is regulated, in part, by epigenetic mechanisms. We investigated the relationship between PLAT methylation and PLAT expression in five primary human cell types and six transformed cell lines. CpG methylation was analyzed...

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Detalles Bibliográficos
Autores principales:	Dunoyer-Geindre, Sylvie, Rivier-Cordey, Anne-Sophie, Caetano, Carlos, Fish, Richard J., Kruithof, Egbert K. O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156355/ https://www.ncbi.nlm.nih.gov/pubmed/27973546 http://dx.doi.org/10.1371/journal.pone.0167588

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