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The In Vitro Effect of Acidic-Pepsin on Nuclear Factor KappaB Activation and Its Related Oncogenic Effect on Normal Human Hypopharyngeal Cells

BACKGROUND: Extra-esophageal carcinogenesis has been widely discussed in relation to the chronic effects of laryngopharyngeal reflux and most prominently with pepsin historically central to this discussion. With refluxate known to include gastric (pepsin) and duodenal (bile) fluids, we recently demo...

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Detalles Bibliográficos
Autores principales: Sasaki, Clarence T., Toman, Julia, Vageli, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156414/
https://www.ncbi.nlm.nih.gov/pubmed/27973541
http://dx.doi.org/10.1371/journal.pone.0168269