Dissecting Torsin/cofactor function at the nuclear envelope: a genetic study

The human genome encodes four Torsin ATPases, the functions of which are poorly understood. In this study, we use CRISPR/Cas9 engineering to delete all four Torsin ATPases individually and in combination. Using nuclear envelope (NE) blebbing as a phenotypic measure, we establish a direct correlation...

Descripción completa

Detalles Bibliográficos
Autores principales: Laudermilch, Ethan, Tsai, Pei-Ling, Graham, Morven, Turner, Elizabeth, Zhao, Chenguang, Schlieker, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156537/
https://www.ncbi.nlm.nih.gov/pubmed/27798237
http://dx.doi.org/10.1091/mbc.E16-07-0511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156537/
https://www.ncbi.nlm.nih.gov/pubmed/27798237
http://dx.doi.org/10.1091/mbc.E16-07-0511

Ejemplares similares