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Myofilament Calcium Sensitivity: Mechanistic Insight into TnI Ser-23/24 and Ser-150 Phosphorylation Integration

Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphory...

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Detalles Bibliográficos
Autores principales: Salhi, Hussam E., Hassel, Nathan C., Siddiqui, Jalal K., Brundage, Elizabeth A., Ziolo, Mark T., Janssen, Paul M. L., Davis, Jonathan P., Biesiadecki, Brandon J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156683/
https://www.ncbi.nlm.nih.gov/pubmed/28018230
http://dx.doi.org/10.3389/fphys.2016.00567