Stabilized Polymer Micelles for the Development of IT-147, an Epothilone D Drug-Loaded Formulation

Epothilones have demonstrated promising potential for oncology applications but suffer from a narrow therapeutic window. Epothilone D stabilizes microtubules leading to apoptosis, is active against multidrug-resistant cells, and is efficacious in animal tumor models despite lack of stability in rode...

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Detalles Bibliográficos
Autores principales: Carie, Adam, Sullivan, Bradford, Ellis, Tyler, Semple, J. Edward, Buley, Taylor, Costich, Tara Lee, Crouse, Richard, Bakewell, Suzanne, Sill, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156807/
https://www.ncbi.nlm.nih.gov/pubmed/28044108
http://dx.doi.org/10.1155/2016/8046739

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156807/
https://www.ncbi.nlm.nih.gov/pubmed/28044108
http://dx.doi.org/10.1155/2016/8046739

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