Cadmium(II) inhibition of human uracil-DNA glycosylase by catalytic water supplantation

Toxic metals are known to inhibit DNA repair but the underlying mechanisms of inhibition are still not fully understood. DNA repair enzymes such as human uracil-DNA glycosylase (hUNG) perform the initial step in the base excision repair (BER) pathway. In this work, we showed that cadmium [Cd(II)], a...

Descripción completa

Detalles Bibliográficos
Autores principales: Gokey, Trevor, Hang, Bo, Guliaev, Anton B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156901/
https://www.ncbi.nlm.nih.gov/pubmed/27974818
http://dx.doi.org/10.1038/srep39137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5156901/
https://www.ncbi.nlm.nih.gov/pubmed/27974818
http://dx.doi.org/10.1038/srep39137

Ejemplares similares